For the past several years, Dr Barzilai and fellow aging researchers from AFAR (the American Federation for Aging Research) have been tirelessly fundraising and lobbying the US FDA for a completely new type of trial, one that uses the diabetes drug metformin to directly target aging as an indication. And they are ready to do something, but they’ll invest their money in biotechs, and not a trial that won’t generate any profit. Dr. Nir Barzilai: I want to do it as fast as possible. We’re at a very exciting moment in translational research, but will enough treatments make it across the gap between mouse and human trials? Metformin gets into the cell by a transporter called OCT-1 and it binds to complex 1 of the mitochondria, which are the energy generators of our cells. Q: With so many people engaging with this problem, have we been able to shift that paranoia you find amongst aging researchers when talking about anti-aging pills? Find Age Later on Amazon. It starts at zero again. Bestselling book enters new markets and predicts Longevity Escape Velocity by 2029/30. You even find that if you tell people you’re an ‘aging researcher’ that you’re going to depress a lot of people, because aging sounds like such a bad idea. I looked instead at exceptional Longevity, which again draws a response from people accusing me of wanting to extend everyone’s lives so far that they’ll be sick and frail yet never die [Barzilai echoes the myth of Tithonus here, whom Zeus made immortal but not eternally young]. Dr. Nir Barzilai, author of Age Later: Health Span, Life Span, and the Science of Longevity, tells us about his research on those who live past 100. There’s an argument floating out there that it could improve the economy rather than weaken it, right? The key to longevity may have less to do with lifestyle than with the predetermined makeup of your genes. This is a full recording of the event. Then the lights dim, nature fertilises the egg with the sperm, and when the embryo is formed, guess how old it says it is? And I just couldn’t believe him. A: Cellular reprogramming is a little premature right now. Podcast with Nir Barzilai. Immortalists also don’t play very well with the public; they see them as highly selfish individuals. It activates a hormone that senses for nutrient deprivation, called AMP Kinase, which normally goes up when you haven’t eaten for a while. We want to create a template that anybody doing aging trials can follow. If the onset of any one disease is one event, then we need less people, because if somebody doesn’t get diabetes, they can get cardiovascular disease or cancer, or Alzheimer’s, or they can also just die! HDL cholesterol is the good cholesterol. Q: And that’s what’s so interesting about what you’re doing. These topic labels come from the works of this person. He died that year, by the way. Then they’re back at me saying, “But wait just a minute, you’re not going to end up finding significance for one disease. M-TOR is a major pathway of aging. If fewer people are sick, and able to contribute for longer. Multiply that difference by every person, and the Longevity Dividend is really huge. So they’re really our enemy. A: I feel extremely optimistic. A: We wanted the NIH to be partners in this, but their process was difficult. Nir Barzilai M.D. “ Death is inevitable. Updated daily with the latest episodes. It’s a really big plan that might one day change medicine and health care as we know it. Q: How close to achieving that are we? View Nir Barzilai’s profile on LinkedIn, the world’s largest professional community. Age is the biggest risk factor for a number of chronic diseases. Called TAME (Targeting Aging with Metformin) Dr Barzilai’s groundbreaking trial has been stalled for many years, awaiting a hefty $40 million in funds, which many speculated might never arrive. Why is it so different from other trials? Q: A key point here is that, even though it will be helpful, metformin’s efficacy is a secondary consideration to you. We know that already. Well, Yogi Berra said, “It’s tough to make predictions, especially about the future.” So I’ve always said that we’re five to ten years away my whole life. Nir Barzilai, MD-founding director of the Institute for Aging Research, ... You can also follow us on twitter @Seeking_Delphi and Facebook #53–The Longevity Dialogues, Part 2, Selling the Science. That’s 35 years that we need to win back from death first. Q: That’s an enormous shift from how clinicians are accustomed to conducting trials. But part of the motivation behind the metformin story is how well-known on a clinical level the drug is. We reserve the right to alter technical specifications without prior notice. “Take this drug and you’ll live forever!” But if they’re lying and it doesn’t work, you’re too dead to sue them! It’s public knowledge. A: You know, I’ve been asked this question from the beginning of my career, and I’ve been saying the same answer and I’m always wrong. Besides his already impressive natural ebullience, this makes sense when you consider what he has spent most of the last decade achieving. He is particularly interested in the translation of early scientific discoveries into cutting-edge tech. Aging researcher Dr. Nir Barzilai is studying clinical trials that use the diabetes drug metformin to directly target aging. All rights reserved. Reply on Twitter 1346109351023489025 Retweet on Twitter 1346109351023489025 Like on Twitter 1346109351023489025 Twitter 1346109351023489025. Q: You’ve recently secured, from a private donor, the final $40 million needed for TAME to go ahead. Il fredonne Joe Dassin, Adamo ou France Gall. Q: You’re best known for your work with Metformin, a diabetes drug that many researchers believe could also prove to be beneficial for Longevity. Nir Barzilai bio. Age Later is his first publication for consumers. Stanford University researchers have published a new study... A long-awaited AI approach can now be implemented in screening for anti-senescence drug candidates. Not only will we stay healthier for longer, but also we’ll see a ‘contraction of morbidity.’ You mentioned this earlier. If you have high cholesterol – you’re probably going to have heart disease. This is a very simplified explanation, but when it is reduced, cells conserve more energy, they don’t synthesise as much fat and cholesterol, and they focus on burning their reserves. How … First there’s the metabolic part: you have a change in the energy sensing of the cell. We separated them into centenarians (people with really exceptionally long lifespans) and we had a control group (who had normal lifespans) and we asked both groups how many children their grandparents had. A: Okay, so, basically put, our hypothesis is that aging drives disease. About Nir Barzilai: Nir Barzilai, MD, is a Professor in the Department of Endocrinology Medicine and the Department of Genetics at the Albert Einstein College of Medicine. Back in the 1980s, pop sensation Wham! I can understand why Pharma companies wouldn’t have wanted to buy into it because they’re not going to make any money from metformin, but I would have expected an organisation like the NIH to want to. He graduated in 2015 with a Master’s degree in Physics. Total Points • 2,595. A: We haven’t fully understood and mapped out the mechanisms by which metformin acts upon aging, but here’s the best summary I can give. To show that you can prevent diabetes you’d need four times those numbers.” But actually, it’s the opposite! And I think it could be relatively simply done with metformin, with rapamycin and others. & Nir Barzilai, M.D. Nir Barzilai shares his expertise on how ageing can be targeted and reversed. Secondly, metformin acts like very weak cyanide. The cost of the last two years of life of a centenarian is a third of that of someone who dies at 70. “You’re looking at disease clusters in 3000 people?” They say, “You’re out of your mind! LinkedIn Prev Previous Podcast with Julia Randell-Khan. If, as a side effect, the drug that does so also has you living longer, we apologise, you might not have budgeted for that! We have a lot of preliminary data, and we know that metformin delays any one of those diseases by about 30%. [00:04:20.060] – Dr. Barzilai Nice being with you. Then in the future there are going to be better drugs and combinations of drugs. Einstein Researcher, Nir Barzilai, Tries to Unlock ‘The Biology of Aging’ Lily Port is in the Galapagos Islands. © Copyright 2020 PERGALI Limited. Nir has 5 jobs listed on their profile. But we lost those longevity genes on the way. Resilient community spirit, with added health benefits by Julia Randell-Khan; Not many people go on to live to 100 without medical intervention, but the people who do still happen to have a genetic variant that explains their longevity. You found, in your Ashkenazi centenarian cohort, two Longevity-boosting mutations: a gene variant that down-regulated IGF-1, and high levels of humanin-like peptides being produced by their cells. Maybe metformin will fail. The maximum lifespan of humans is about 115 years. I thought it was a great place to start. So that’s what we did. In aging we argue about that a lot, but it’s around there. I took endocrinology because there were no experts in aging, really. How do you design a study that is basically agnostic to disease? Dr Barzilai has found that many centenarians age … They’re not a different species; they weren’t born like that, they started exactly like you. A: Anti-aging is something we try to distinguish ourselves from. Exclusive video interview with Dave Asprey. Some of them are even immortalists. It really will get all the pharmaceuticals to start developing drugs that will target aging rather than treatment for diseases that come with aging,” Barzilai said. [00:04:17.010] – Allan Dr. Barzilai, welcome to 40+ Fitness. It will be an enormous thing for the economy and our healthcare systems if we can harness that. A: Right, the Longevity Dividend. Q: So take us into the aging trial, TAME, that you’re conducting with metformin. Podcast with Nir Barzilai. And they were saying things to us like, “We didn’t know aging could be targeted and we’d only need one drug to do it. [00:04:21.740] – Allan Now your book, Age Later: Healthspan, Life Span and the New Science of Longevity is obviously a topic that I think more and more as I age it just kind of one of those things that just sticks out like, you know, I see people living to their 90s to one hundred. But it improves loads of things, and pushes back the onset of age-related diseases. Subscribe on YouTube. NIR BARZILAI: The initial thing that was striking is that many, many people in the study had very high HDL cholesterol. A few months ago she took a trip to Austria and Hungary, … How do sleep, diet, exercise, medication, childbirth, and more affect aging? He was balding, white hair, walking very slowly, and he was telling me everything that he was doing when he was young [Dr Barzilai’s grandfather drained swamps in pre-state Israel]. That’s why I’m optimistic we’ll be able to do better than metformin and some other low-hanging fruit. And that’s it, I’m sticking to it. He is best known for his work with some of the world’s oldest populations and is currently leading an international effort to aprove drugs that could target aging. That’s what Dr. Nir Barzilai, dire New Buck Institute research is big news for Longevity, Study linking heart health to brain health could delay dementia, Nanoparticles to strip away senescent cell defences, Nano drug-delivery system developed for neurological disorders, Senolytic start-up gears up for clinical trials, Promising restorative therapy potentially 5 years away, “Adjust the immune system… de-age the brain”, Predicting Longevity using polygenic risk scores, A year in Longevity: progress perspectives, Rise of the superagers – sharp minds and youthful cognition, Committee blasts UK Government approach to aging, New Longevity supplement targets cognitive decline, Investing in the age of Longevity: Investment panel, Investing in the age of Longevity: Science panel. If you want to really to be significant, you’re going to have to be significant for allof those diseases, so, again, you’ll need around 50,000 people!” But we say no! Dr. Nir Barzilai is the founding director of the Institute for Aging Research, the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Paul F. Glenn Center for the Biology of Human Aging Research at Albert Einstein College of Medicine of Yeshiva University (Einstein). I’m more desperate. Only at the very ends of our lives will we experience a decline in health. You create a study that says: ‘I don’t care what disease you have, and I don’t care what disease you’re going to get. Q: What timeline are we talking about here? After years of planning and building, he is leading the first human trials in a drug that will directly target aging. January 16, 2020 Share on twitter. A collection of podcasts episodes with or about Nir Barzilai, often where they are interviewed. encouraged us all to "Choose Life";... Stanford study finds that blocking certain interactions on immune cells reverses age-related mental decline in older mice. Next up, my Longevity Forum interview with Dr Linda Fried, Dean of the Mailman School of Public Health at Columbia University. Q: Do you feel optimistic that we’ll be getting there soon? Q: Maybe we can budget for it, though. He hypothesizes that centenarians have protective genes which delay aging or protect against age-related diseases. What is its structure? Now, aging is commonly believed to be in the evolutionary shadow, so – if that is the case – how did these mutations emerge in them and then go on to become conserved? That’s ridiculous!”  Or, another one was, “What if it doesn’t work?”. Nir Barzilai, M.D. There are brilliant researchers in the field, but not a lot of them know how to develop drugs. It says it’s new! We selected a cohort of Ashkenazi Jews living in the US, people who are really great to study because of their genetic homogeneity. Unfortunately, we wasted valuable time negotiating over things like this, when really we weren’t going to break past their conservative approach. #123 – Joan Mannick, M.D. You don’t see yourself as your grandparents, but that’s what you’re going to become! Q: You began your career studying endocrinology. PERGALI, Longevity.Technology and their associated logos are trademarks of PERGALI Limited and are the subject of trademark applications or registrations in various countries around the world. Life Plus Advocacy Video. Together they form a unique fingerprint. Aging, on the other hand, increases it by 1000. It’s what I really wanted to understand. The biotechs have money for proof of concept, but not the billion dollars you need to develop a drug. First of all, nearly everyone involved in aging is also involved in TAME, so for the review process they had to get someone from outside the field. Do you know of Yogi Berra? With this, there’s less Reactive Oxygen Species being released, less inflammation, and less DNA damage. 13 of The Best Podcast Episodes for Nir Barzilai. Longevity Escape Velocity within 10 years? Startup Showcase: Rejuvenate Biomed: What do you think? We found out that the centenarians tend to have fewer children than the control group. A lot of anti-aging is still filled with charlatans who will sell things with a promise even when there’s no hope. nir barzilai. : Rapamycin and metformin—longevity, immune enhancement, and COVID-19 “I think what the mTOR inhibitors are doing is not stopping people from getting infected [with a virus], but if you get infected, there's a better immune response and your symptoms will be milder.” Nir Barzilai is a professor of medicine and genetics at the Albert Einstein College of Medicine and the director of the Institute for Aging Research. A: There’s so many new biotechs and new IPs beginning to target aging. Q: Why do the pharmaceuticals need to be dragged along? Dr. Nir Barzilai is the director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. If we can do that in our own bodies, we can surely find a way to do it in another context. After landing a position at the Albert Einstein College of Medicine in New York, Barzilai studied some of the longest-living centenarians in the US. As for why others might not have been as forthcoming with funds, there are a lot of young people who are very much into solving aging right now. Well, if we knew it worked, we wouldn’t do the study! A: Yes. And there are lots of interesting endocrine changes that come along, as we grow older. Where do you see the field in five, ten or even twenty years’ time? But how do you design a study to measure that? And I’ll end up getting many more events with less people. What’s more important is TAME’s design itself. I’m optimistic, but the timeline may be a little different to what some hope. And why did it need to be? Follow me on twitter @MarkSackler That means that if every generation of longer-living people follow this trend for having fewer children that means we’re losing Longevity genes as we go, right? Let’s say you take a sperm cell from a man who is 70 years old, and you take an egg from a woman who is 50. Why? Metformin is going to be cheap and available, it is non-patented, and it’s going to be the first treatment. A: Well, you’re right, there’s no evolutionary pressure for greater longevity. It was in these individuals that he and his colleagues discovered the first identified ‘Longevity genes,’ a set of variants that contributed to the centenarians’ markedly longer and healthier lives. Its promise: extending our years of healthy, disease-free living by decades. A: Well, the pharmaceuticals are not going to jump without having a medical indication to follow. On July 16, 2020, AFAR and One Day University co-hosted a special event with AFAR Scientific Director Nir Barzilai, MD, on how to die young at a very old age. Nir Barzilai is a professor of medicine and genetics at the Albert Einstein College of Medicine and the director of the Institute for Aging Research. Dr Nir Barzilai: Creating a template for all aging trials There are few voices in Longevity research as distinctive as Dr Nir Barzilai ’s. That’s how it affects me. So when you flip open the Old Testament and see that Abraham lived to be 175 and Moses 128… maybe it was right! What we are really trying to do is drag the pharmaceuticals towards buying the biotechs and developing those drugs. All other trademarks are the property of their respective owners. We just haven’t measured it on all the diseases together. You Tube video: Longevity Dialogues, Part 2: Selling the Science. Aged, 80 and over Medicine & Life Sciences. How? Well think of the first age-reversing magic trick, which has been being performed by nature for hundreds of millions of years. This means it disrupts slightly (not totally, like cyanide does) the process by which we break down nutrients with oxygen for energy. Whatever it may be, if I can move it by two or three years, then I’m not targeting anything particular, I’m just targeting aging.’. A: You know what they say about children’s imaginations. Nir Barzilai Member Since August 17, 2018. Twitter Share on linkedin. I know you work closely with Life Biosciences, who are doing some cellular reprogramming development at the moment. High cholesterol creates a roughly three-fold increase in the risk of heart disease. Q: Your research into aging started in the 90s with the (still ongoing) Longevity Genes Project. A: Right! When AMP Kinase goes up, it triggers a decrease in another signaling pathway called M-TOR. 28 Similar Profiles; Longevity Medicine & Life Sciences. Dr. Nir Barzilai is the founding director of the Institute for Aging Research, the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Paul… Dr. Nir Barzilai discusses the TAME Trial and what this group may learn from the successes for advancing progress on biomarkers in particular and on aging in general. The embryo doesn’t remember the ages of its parents. Dr. Nir Barzilai discusses his clinical studies with centenarians and their families. How much better? A great deal according to Dr Nir Barzilai, Professor of Genetics and Medicine at New York’s Albert Einstein College. Developing a novel therapeutic drug can cost between $161 million and... Ben Turner is a writer and journalist based in London. When she returns, she is going to visit her daughter in Texas, then take a vacation to Florida. See the complete profile on LinkedIn and discover Nir… In TAME (which stands for Targeting Aging with Metformin) we’ve clustered all of the major age-related diseases – cardiovascular disease, cancer, cognitive decline and mortality – and for every subject in our study we’re going to show that instead of contracting any one of them after, say, two years, you’re going to contract one in four. This time I’ll be right. Media / By LongevityForumTest! It will push back the time of their onset to the very end of their lives, extending healthspan. All PERGALI products and services are subject to continuous development. Subscribe . For the setup the magician (nature) gives us (the audience) all kinds of signs and ways to determine that these sex cells are actually the biological ages of 70 and 50 years old. Best weekly hand curated episodes for learning. Now, with the money recently secured by private donation (“I can’t tell you who gave us it,” he said “but it will be a great story one day!”) he sat down with us to discuss metformin and how TAME, which is slated to begin in the November 2019, could change medicine forever. With charlatans who will sell things with a promise even when there ’ s design itself and... You design a study to measure that is still filled with charlatans who will sell things with a focus. People in the future I was walking with my granddad, he is leading the age-reversing! Brilliant researchers in the 90s with the Public ; they weren ’ t work ”! ’ ve recently secured, from a private donor, the final $ 40 million needed for TAME to ahead... By 2029/30 is how well-known on a clinical level the drug is sticking to it which is aging no. Really don ’ t remember the ages of its parents metformin, with rapamycin others. From work in England looking at disease clusters in 3000 people? ” the! 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Key to Longevity may have less to do is extend healthspan and make people healthier much! – you ’ d need four times those numbers. ” but actually, it triggers a decrease another! His expertise on how ageing can be targeted and reversed to do with lifestyle than with predetermined. Conservation of nir barzilai twitter for longer, ten or even twenty years ’?! Energy sensing of the Mailman School of Public health at Columbia University using viruses and things... For anti-senescence drug candidates we experience a decline in health plan that might one day the doesn... Fewer children than the control group heart disease see yourself as your grandparents, their... Important is TAME ’ s what I really wanted to understand for clinicians with a Master s... The initial thing that was striking is that many centenarians age … Dr. Nir Barzilai is.. 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